P0300 on Toyota Highlander
Random/Multiple Cylinder Misfire Detected
Methodology: Reviewed against the SAE J2012 generic DTC definition and NHTSA owner-complaint patterns, then scoped to Toyota Highlander context without treating complaints as confirmed diagnoses.
Sources: SAE/OBD-II definitions, manufacturer service information, and public reliability reports (including NHTSA where applicable).
- SAE J2012 Diagnostic Trouble Code Definitions — Generic diagnostic trouble code definition reference for P0300.
- NHTSA recalls, complaints, and manufacturer communications — Used to check public owner complaint context, recall status, and safety-related manufacturer communications by VIN or vehicle.
Limits: Guidance is informational and may not match every model-year or revision. Confirm with the official manual and diagnostics before replacing parts. For safety-critical or electrical work, use a qualified technician.
What P0300 Means on Your Toyota Highlander
P0300 is a diagnostic trouble code indicating: Random/Multiple Cylinder Misfire Detected. This code relates to the ignition system system. The vehicle's computer detected a condition outside normal operating parameters and stored this code.
Real Toyota Highlander Owner Reports
Source: NHTSA Complaints Database
"1. The 3.5L V6 Engine (2GR-FE) failed due to the subsequent loss of lubrication caused by the rupture of the Oil Cooler Pipe (Rubber component), a manufacturing defect known under TSB T-SB-0201-11 (ZE2 Program)."
"I experienced a sudden engine failure while driving my 2015 Toyota Highlander on Interstate 294 outside Chicago. I was driving about 75 mph in the far left lane."
"Vehicle went into limp mode reieved code p0300 reduced engine power on highway when accelerating"
All reports filed by vehicle owners directly with the U.S. Department of Transportation.
📊 Complaint Trend by Model Year
Common Causes on Toyota Highlander
Based on NHTSA complaint component analysis for this vehicle.
What To Do Next
-
1
Check for recalls on YOUR VIN
Go to nhtsa.gov/recalls and enter your VIN. If your vehicle is covered, repairs are free.
-
2
Get a proper diagnosis
A code alone doesn't tell you the exact failed part. A diagnostic at a shop ($50–$150) pinpoints the root cause before you spend money on parts.
-
3
Compare repair quotes
Get 2–3 quotes. Dealer vs. independent shop prices often differ 30–50% for the same repair.